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Spheroid Formation of Hepatocarcinoma Cells in Microwells: Experiments and Monte Carlo Simulations

Fig 1

Scheme of SpheroFilmTM scaffold and spheroid formation there.

(a) Top view of SpheroFilmTM containing 361 (19 × 19) microwells; [(b) and (c)] shape and dimensions of microwells with a diameter of 500 μm and the total well depth of 1000 μm; (d) cell seeding and attachment in and outside of microwells; (e) side and top views of spheroid formation in microwells; (f) side and top views of cell growth in and outside of a microwell.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0161915.g001