Evaluation of Tetrahydrobiopterin Therapy with Large Neutral Amino Acid Supplementation in Phenylketonuria: Effects on Potential Peripheral Biomarkers, Melatonin and Dopamine, for Brain Monoamine Neurotransmitters
Fig 6
Urine dopamine vs. Plasma phenylalanine.
The number of each data point indicates the study phase. Negative correlations with plasma phenylalanine concentrations and urine dopamine (p = 0.047) are shown. Except for S7, a linear negative regression line is drawn for each subject.