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Identification of Novel Smoothened Ligands Using Structure-Based Docking
Fig 5
Structures of the antagonists discovered in the analogs screen.
The table includes their IC50 in the Gli-Luciferase assay in Ptch1-/- MEFs, and their Tc score compared to the closest known Smo ligand.
doi: https://doi.org/10.1371/journal.pone.0160365.g005