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Identification of Novel Smoothened Ligands Using Structure-Based Docking

Fig 4

Screening of analogs and dose-response analysis of best hit.

(A) Second screen at 30 μM using the 8xGli-Luciferase reporter in Ptch1-/- MEFs. vismo: vismodegib at 100 nM. (B) Dose-response analysis of compound 45b using the 8xGli-Luciferase reporter in Ptch1-/- MEFs. n = 3 (C) Dose-response analysis of compound 45b by qPCR of Gli1 expression in Ptch1-/- MEFs. n = 3, combined experiments, error bars: standard deviation.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0160365.g004