Ligand Similarity Complements Sequence, Physical Interaction, and Co-Expression for Gene Function Prediction
(A) Performance of the networks as measured by the AUROC, average precision and average fold change precision. The black points represent the full network as assessed on a GO subset. The green points show the performance of the 1% sparsified network, while the blue the optimized version. (B) The topology of the BlastP sequence similarity network. The original, once optimized, has few connections, mostly pairs and cliques.