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Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel

Fig 7

Hot-spots in the transmembrane domain.

View of the transmembrane domain from the extracellular side. Highly correlated residues are blue. Note the lack of such residues lining the lumen or exposed to the lipid bilayer, describable as a tube-like geometry in which hot-spots are located within the volume of the tube, but not on either inner or outer surfaces.

Fig 7