Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel
(a) Highly correlated residues (hot-spots) in the internal allosteric network (highlighted in blue), derived from the consensus residue correlation matrix of free GLIC and all single-ligand-GLIC simulations. (b) List of these residues, shown with an “X” mark, for various binding conditions. Note the high degree of commonality. For reference, propofol (yellow), desflurane (blue), and ketamine (green) are shown in their crystallographic binding sites.