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Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel

Fig 4

Visualizing the consensus residue correlation matrix: regions of high and low correlation scores.

Residues of low correlation score are colored grey, while those of high correlation score are colored orange. Note the distribution of high-correlation residues in the transmembrane and EC-TMD interfacial regions in both (a) side view and (b) view through the pore lumen, looking in from the extracellular side.

Fig 4

doi: https://doi.org/10.1371/journal.pone.0158795.g004