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Common Internal Allosteric Network Links Anesthetic Binding Sites in a Pentameric Ligand-Gated Ion Channel

Fig 3

Tilt angles of key GLIC domains with and without ligand binding.

Scatter plots of tilt angles of extracellular domain leaflet (left column of plots) and TM2 pore-lining helix (right column of plots) for each of the five GLIC subunits (labeled A–E), in free and bound states. The occupied transmembrane binding site is in subunit E, and the occupied extracellular ketamine binding site is between subunits E and A. Note the relatively symmetrical distribution of tilt angles in the free state and asymmetric distributions in all bound states.

Fig 3