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Efficacy and Safety of Azithromycin-Chloroquine versus Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment of Plasmodium falciparum Malaria Infection in Pregnant Women in Africa: An Open-Label, Randomized Trial

Fig 1

Participant flow chart.

aThe reasons why study participants were no longer willing to participate included: no specific reason provided, n = 17; family, social, or personal issues, n = 17; experience of AEs, n = 16; no longer willing to take study drug, n = 6; relocation, n = 3; stillbirth, n = 1. bThe reasons why study participants were no longer willing to participate included: family, social, or personal issues, n = 10; relocation, n = 3; no specific reason provided, n = 2. cThe AEs leading to discontinuation were combinations of nausea, vomiting, asthenia, spontaneous abortion, imminent abortion, and restlessness. dThe AE leading to discontinuation was premature rupture of membranes/stillbirth/umbilical cord abnormality. eThe causes of deaths were meningitis; postpartum hemorrhage and uterine rupture; and eclampsia. fThe death was due to peritonitis and intestinal perforation. gThe ‘other’ reasons for discontinuation were: relocation, n = 9; family, social, or personal issues, n = 5; non-compliance with study procedures, n = 2. hThe ‘other’ reasons for discontinuation were: relocation, n = 5; family, social, or personal issues, n = 5; no specific reason provided, n = 1.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0157045.g001