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Mutations Designed by Ensemble Defect to Misfold Conserved RNA Structures of Influenza A Segments 7 and 8 Affect Splicing and Attenuate Viral Replication in Cell Culture

Table 1

Naturally occurring counts of WT and corresponding mutated amino acids for the listed mutant PR8 viruses.

Mutations in 7MB_ED and 8PK_BP are silent. All sequences were downloaded from the National Center for Biotechnology Information (NCBI) resource. Unique sequences were extracted from the alignment, and the total number of unique sequences is listed in the last column.

Table 1

doi: https://doi.org/10.1371/journal.pone.0156906.t001