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Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma

Fig 5

Upstream regulation with stage.

(A) Heatmap of six upstream targets predicted to be activated/inhibited in tumor versus normal at each ccRCC stage and using all stage data together. Scale is activation z-score, with ≥ 2 being likely activation and ≤ -2 being likely inhibition. Using all stage data together, activated or inhibited upstream targets (ESRRA, ESRRG, HIF1A, FOXA1, MAPK1, and WISP2) are shown. (B) Heatmap of six upstream targets predicted to be activated/inhibited in tumor versus normal-adjacent tissues using the proteomic data set. Corresponding activation z-scores from transcriptomic data analysis are included to demonstrate conserved trends at each ccRCC stage and using all stage data together.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0154074.g005