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Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma

Fig 3

Enriched pathways related to metabolic dysfunction in ccRCC.

Pathway enrichment analysis using IPA was performed using the 344 proteins with differential abundance between normal and tumor samples. Of the 88 pathways identified at an FDR < 5% and containing more than one protein, the following top 13 pathways are shown based on their relationship to Warburg effect related changes. The ratio of enrichment (or % observed) is further divided into those proteins increased or decreased in tumor samples. The total number of possible (or expected) proteins in each pathway is given to the right of the bar.

Fig 3

doi: https://doi.org/10.1371/journal.pone.0154074.g003