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Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma

Fig 1

Differential protein abundance and gene expression between tumor and normal-adjacent ccRCC tissues.

(A) Heatmap of 344 proteins with differential abundance between tumor and normal-adjacent samples (moderated t-test, Benjamini-Hockberg adjusted p-value < 0.05). (B) Heatmap of 1003 genes with differential expression between 94 tumor and normal-adjacent samples (moderated t-test BH adjusted p < 0.001 and absolute fold-change ≥ 4). Scale bar is standard deviation units around the mean of each protein abundance or gene expression level.

Fig 1

doi: https://doi.org/10.1371/journal.pone.0154074.g001