Dasatinib Reduces Lung Inflammation and Fibrosis in Acute Experimental Silicosis
Fig 7
(A) Representative photomicrographs (polarized light microscopy) of lung parenchyma, stained by Picrosirius red, of C-DMSO, C-DAS, SIL-DMSO, SIL-DAS. Collagen fibers are shown in orange. 100× magnification. Scale bars = 50 μm. (B) Collagen fiber content quantification in lung parenchyma and granuloma. Lung tissue protein levels of TGF-β quantified by ELISA. White bars: DMSO; gray bars: DAS. Values are means (± SD) of 8–9 animals per group. *Significantly different from C-DMSO group (p < 0.05). #DMSO vs. DAS (p < 0.05).