Computational Trials: Unraveling Motility Phenotypes, Progression Patterns, and Treatment Options for Glioblastoma Multiforme
Fig 5
Predicting patients response and survival times.
(a) is a Kaplan-Meier analysis of the overall survival of the four tumor groups in the computational trial. There are three treatment groups: 30 highly-dispersive Tumors (blue), 25 moderately-dispersive (red), and 25 hypoxia-driven Tumors (Black). The control group (green) includes 75 untreated tumors from all three tumor groups. The difference in overall survival between the highly-dispersive tumors and all other groups is significant (Log-Rank p < 0.01); the differences between moderately-dispersive and both the hypoxia-driven and untreated groups is not significant. (b) is a cartoon that illustrates how the motility phenotypes can predict both the patterns of progression and the overall survival times (blue arrows).