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PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer

Fig 7

PEAK1 and TGFβ cooperate to promote resistance to Src kinase inhibition.

(A) Indicated populations of MCF7-Vector and–PEAK1 cells were plated on fibronectin and treated with increasing doses of either AZM (left) or SB-431542 (right). After 72 hours an AQueous One assay was performed to assess cell viability. Relative cell number versus drug concentration (M) is plotted. (B) AZM IC50 values for are reported for the indicated cell population.

Fig 7

doi: https://doi.org/10.1371/journal.pone.0135748.g007