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PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer

Fig 5

PEAK1 is required for TGFβ/fibronectin-mediated metastasis in vivo.

(A and B) CA1h-shCntrl and–shPEAK1 cells were plated on fibronectin then treated with TGFβ for 72 hours, after which a CAM assay was preformed. (A) After harvesting the primary tumor, it was weighed. (B) qPCR for chicken GAPDH and human alu was performed on genomic DNA extracted from the liver and lung tissue. A t-test was performed to determine statistical significance. *, **, *** indicate p-values < 0.05, 0.01 and 0.001, respectively.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0135748.g005