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PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer

Fig 4

PEAK1 cooperates with fibronectin to block the cytostatic effects of TGFβ.

MCF7-Vector and–PEAK1 or CA1h-shCntrl and–shPEAK1 cells were plated on fibronectin then treated with TGFβ. (A and C) After 72 hour incubation, an AQueous One assay was performed. The relative cell number was plotted and two-way ANOVA analysis was performed to determine statistical significance. (B and D) The cell cycle profiles were analyzed and the percent of cells in each stage are shown. *, **, *** indicate p-values < 0.05, 0.01 and 0.001, respectively.

Fig 4