Innate Multigene Family Memories Are Implicated in the Viral-Survivor Zebrafish Phenotype
Fig 3
Comparison of Enrichment Scores (ES) for individual genes from GSs with significant NES.
Some of the most enriched human/zebrafish orthologous GSs of Table 1 were compared by their corresponding individual gene enrichment plots (ES per gene in the Y axis versus ranked list of genes ordered from their highest to lowest differential expression folds in the X axis). Those genes ranked first in the X axis correlated with the first phenotype of the comparison (VHSV+, VHSVS, VHSVS+) while those at the end correlated with NI. Black circles, crp (c-reactive protein) keyword-selected GSs with added complement components (genes listed in S4 Table). Red circles, mx (myxovirus-induced protein) keyword-selected GSs with added interferon genes (S4 Table). Green circles, nitr (novel immune-type receptor) keyword-selected GSs (S4 Table). Blue circles, “Proteasome degradation” WIKI pathway (S4 Table). Open circles, “complement and coagulation cascades” KEGG pathway (S4 Table). Red squares, “Type II interferon signaling (ifng)” WIKI pathway (S4 Table). Red triangles, ifn (interferon) keyword-selected GSs (S4 Table). The complete list of zebrafish GS genes in the in-house microarray and their corresponding probe sequences can be found at GEO’s GPL17670.