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Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma

Fig 6

Toxicity assessment after dose-escalation study in pigs.

A dose-escalation study comparing CED of carboplatin NP with aCSF (co-infused with 0.2% Gd) was conducted in a porcine model. (A) Widespread putamenal distribution was observed using real-time MR imaging (B) Fluorescence immunohistochemistry demonstrates intact neuronal (E & L) and glial (D & K) networks at the site of infusion. Repeat dosing of carboplatin NP was not associated with increased macrophage activation compared to control (G & N). Minimal toxicity was also confirmed by maintenance of cellular architecture (H & O) (Scale bar; 250μm in magnified images, 100μm in images showing entire section (B&I)

Fig 6