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Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma

Fig 5

Toxicity analysis after CED into the striatum of rat brains.

CED of aCSF (negative control), carboplatin (0.72mg/ml; 5μl volume) (or carboplatin NP (1mg/ml; 5μl volume) was conducted and toxicity in rat striatum assessed. Dual IHC analysis of neurons (NeuN) and Glial cell (GFAP) demonstrated minimal toxicity localised to the needle track. No glial or neuronal cell loss was observed elsewhere. Scale bar: 100μm.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0132266.g005