Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma
Immediately after CED, nanoparticles distribute throughout the striatum. (A) CED of aCSF alone (5μl volume) or fluorescein-labelled carboplatin NP into the striatum of rat brain was conducted (1mg/ml; 5μl volume). These were analysed by sectioning around the needle track and counterstaining with DAPI (Scale bar; 250μm). (B) Carboplatin NP show increased tissue retention after 24 and 48 hours. Following CED of carboplatin NP (1mg/ml; 5μl volume), punches of the brain tissue obtained around the site of infusion were analysed by ICP-MS. Paired t-test analysis revealed a significant increase in the tissue half-life of carboplatin NP at 24 hours (indicated by asterix).