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A Genetic Porcine Model of Cancer

Fig 4

Inducible expression of KRASG12D and TP53R167H is tumorigenic in transgenic pigs.

(a–c) Ultrasound images of tumors developing 10 days after, and (d–f) images of these tumors at necropsy 20 days after intramuscular (IM, Pig 1), subcutaneous (SQ, Pig 3), or intra-testicular (IT, Pig 1) injection of AdCre in transgenic oncopigs containing a Cre-inducible vector encoding KRASG12D and TP53R167H; (g–i) H&E stained sections show the tumor and adjacent normal tissue (2x) with an inserted high magnification photo (20x).

Fig 4

doi: https://doi.org/10.1371/journal.pone.0128864.g004