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Radiation Induced Chromatin Conformation Changes Analysed by Fluorescent Localization Microscopy, Statistical Physics, and Graph Theory

Fig 5

Conditional Probability Distribution of the Edge Lengths.

Panel A. The panel shows the conditional probability distribution p(r|r′) of the edge lengths for the H2B markers before irradiation. The relatively prominent diagonal indicates locally a varying density. Panel B. The panel shows the conditional probability for the H2B markers 30 minutes after irradiation. Panel C. The panel shows the conditional probability for the H2B markers 48 h after irradiation. Panel D. The panel shows the difference of the conditional probabilities p(r|r′) measured for structures recorded before irradiation and for structures registered 30 min after irradiation. Shades towards red indicate values which are larger in the samples before irradiation, while values towards the shades of blue indicate probabilities which are larger in images registered 30 min after irradiation. The plot indicates slightly increased values along the diagonal after irradiation. This might mean a slightly increased clustering of the points. Panel E. The panel shows the differences of the conditional probability before irradiation and 48 h after irradiation. Entries in shades of red are larger in samples recorded before irradiation, while entries in shades of blue are larger in the samples recorded 48 h after irradiation. The trend is similar to that observed in panel D, however differences are less prominent. Panel F. The panel shows the differences if the conditional probability measured 30 min and 48 h after irradiation respectively. The red shades indicate larger probabilities in samples recorded 30 min after irradiation while blue shades indicate larger probabilities in samples registered 48 h after irradiation. Here a reversed trend compared to panel D was observed.

Fig 5

doi: https://doi.org/10.1371/journal.pone.0128555.g005