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Fitness Consequences of Advanced Ancestral Age over Three Generations in Humans

Fig 1

Representation of the data structure for calculation of weighted mean age of male ancestors (WMAMA).

The ages at which the male or female proband’s male ancestors (white squares) fathered the proband and the proband’s ancestors were used, weighted by the degree of mean relatedness. Grey circles represent the proband’s female ancestors, whose ages were not used in the calculation (maternal age was controlled for in the models; see Methods). Individuals in our data set had at least both grandfathers known, with varying numbers of great-grandfathers, a factor which was accounted for in the calculation (see Methods).

Fig 1