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Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells

Fig 1

PCT analogs reduced viability of human head and neck cancer cells (SCC25 and SCC104) in a dose-dependent manner.

(A-C): 1×104 cells of each type were treated with TM-025 and TM-026 for 24, 48 and 72 h (A, B and C, respectively) in increasing concentrations (1, 10, 100, 500, 1000 and 5000 nM). Percentage viability of SCC104 and SCC25 cells (estimated by MTT assay) were significantly (P<0.05) reduced with higher doses of both analogs. (D): Effect of 48 h treatment of the parent compound PCT in SCC25 and SCC104 cell lines. All experiments have been performed in triplicates, and results obtained have been plotted as the data means (±SEM).

Fig 1