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Analysis of Antibody Aggregate Content at Extremely High Concentrations Using Sedimentation Velocity with a Novel Interference Optics

Fig 1

Interference detectors of the Optima XL-I ultracentrifuge (left) and the custom-built Aida ultracentrifufe (right).

The larger camera surface of Aida allowed for a higher optical magnification factor of 2 vs. 1.75 in the XL-I centrifuge after adapting the lens system accordingly. Additional improvements are described in the text.

Fig 1