BAP1 Missense Mutation c.2054 A>T (p.E685V) Completely Disrupts Normal Splicing through Creation of a Novel 5’ Splice Site in a Human Mesothelioma Cell Line
Fig 1
Comparative sequence analysis reveals the BAP1 c.2054A (p.E685) is highly conserved.
A. Multi-species comparative genomic analysis of BAP1 c.2054A in ten distantly related species: human, chimpanzee, mouse, rat, dog, cat, rabbit, chicken, xenopus and zebrafish. B. Multiple sequence alignment indicates BAP1 p.E685 is well conserved across the same ten distantly related species.