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How Difficult Is Inference of Mammalian Causal Gene Regulatory Networks?

Figure 4

Fold changes (log) from tooth microarray perturbation experiments that matched the perturbation evidence in the literature show consistency with expected trends.

RTPs that are inhibiting (A), have no effect (B), or are activating (C) trend to have negative, close to zero and positive fold changes respectively. (D) shows the consistency of the literature based RTP type (Lit.) and microarray data (M.A.) as fold change cut-off varies between 0 and 3 (both up- or down-regulation).

Figure 4

doi: https://doi.org/10.1371/journal.pone.0111661.g004