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Directional Influence between the Human Amygdala and Orbitofrontal Cortex at the Time of Decision-Making

Figure 3

Spectral conditional Granger causality comparisons.

(A–C) Spectral CGC between amygdala and OFC contacts, computed over all trials for the interval −1 s to +1 s relative to stimulus onset. The CGC magnitudes as a function of frequency were computed using all contacts shown in Figure 2. Amygdala-to-OFC is shown in red, and OFC-to-amygdala is shown in black. A two-sided cluster-based permutation test for net CGC was performed for each subject by random rearrangement of trials for each contact. For each subject, the null permutation distribution was used to determine the largest-to-smallest net CGC statistic with FWER controlled at.05. Net CGC is given by the CGC from amygdala-to-OFC (red) minus the CGC from OFC-to-amygdala (black). Significant (p<.05) clusters are denoted by *. The maximum cluster (joint contact-pair and frequency) was identified for each subject and is depicted by the gray bar.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0109689.g003