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Intra-Lesional Injection of the Novel PKC Activator EBC-46 Rapidly Ablates Tumors in Mouse Models

Figure 3

EBC-46 treatment induces greater effects when injected into tumors compared to normal skin.

EBC-46 was injected into male BALB/c Foxn1nu mice either bearing (n = 9) or not bearing (n = 9) tumors, as a single intra-lesional or sub-cutaneous injection, respectively. A. Erythema at injection site 24 hours following treatment with 50 nmol (30 µg) EBC-46 in tumor- or non-tumor-bearing mice. B. Oedema at injection site 24 hours following treatment with 50 nmol (30 µg) EBC-46 in tumor- or non-tumor-bearing mice. C. Percentage weight change 24 hours following treatment with 50 nmol (30 µg) EBC-46 in tumor- or non-tumor-bearing mice. D. Concentration in serum following treatment with 50 nmol (30 µg) EBC-46 in tumor- or non-tumor-bearing mice. Data is from serum from three animals unless otherwise indicated. Error bars – SEM. (**, p<0.01; ***, p<0.005; t-test). a - single data point from EBC-46-treated animals. b - below lower limit of detection of the assay, set at 0.01 ng/ml.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0108887.g003