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Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons

Figure 5

Perampanel does not inhibit NMDA-evoked currents in cultured hippocampal neurons.

(A) Sample currents evoked by 10 and 100 µM NMDA in the absence (left panels) and presence (right panels) of perampanel (30 µM). (B) Mean ± S.E.M. peak amplitude of currents evoked by 10 and 100 µM NMDA during control conditions (bath perfusion) and in the presence of perampanel. (C) Mean ± S.E.M. late amplitude of currents evoked by 10 and 100 µM NMDA during control conditions (bath perfusion) and in the presence of perampanel. Each bar represents data from 6 neurons.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0108021.g005