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Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons

Figure 4

Kinetics of peramapanel block of AMPA-evoked currents.

(A) Time constants for block and unblock of 100 µM AMPA-evoked currents determined from the best single exponential fits to current traces at the onset (τapp) and termination (τoff) of application of 1, 3 and 10 µM perampanel. (B) Reciprocal mean τapp values ( = kapp) plotted against perampanel concentration. The best-fit straight line to the data is shown. The slope and the intercept values are 1.5±0.1×105 M−1 s−1 and 0.58±0.6 s−1, respectively.

Figure 4

doi: https://doi.org/10.1371/journal.pone.0108021.g004