Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons
(A) Time constants for block and unblock of 100 µM AMPA-evoked currents determined from the best single exponential fits to current traces at the onset (τapp) and termination (τoff) of application of 1, 3 and 10 µM perampanel. (B) Reciprocal mean τapp values ( = kapp) plotted against perampanel concentration. The best-fit straight line to the data is shown. The slope and the intercept values are 1.5±0.1×105 M−1 s−1 and 0.58±0.6 s−1, respectively.