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Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons

Figure 3

Slow onset and recovery from perampanel block of kainate- and AMPA-evoked currents.

(A) Currents evoked by 100 µM kainate in the absence (A1) and with pre-application (A2), co-application (A2) and post-application (A3) of perampanel (3 µM) in the same neuron. (B) Currents evoked by 100 µM AMPA in the absence (B1) and with pre-application (B2), co-application (B2) and post-application (A3) of perampanel (3 µM) in a different neuron from (A). Open arrows indicate peak current levels in the case of AMPA-evoked currents and the current at 100 ms after onset of agonist application in the case of kainate-evoked currents; closed arrows indicate late current levels (end of agonist application). Scale for current is 300 pA in (A) and 500 pA in (B). (C) Mean ± S.E.M. values of peak (C1) and late (C2) current levels as a percent of control (as in A1) with perampanel pre-application (as in A2), co-application (as in A3) and post-application (as in A4) in 3–4 neurons (D) Mean ± S.E.M. values of peak (D1) and late (D2) current levels as a percent of control (as in B1) with perampanel pre-application (as in B2), co-application (as in B3) and post-application (as in B4) in 4 neurons. *p<0.05 vs. A2 or B2.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0108021.g003