Perampanel Inhibition of AMPA Receptor Currents in Cultured Hippocampal Neurons
(A) Sample currents evoked by 100 µM kainate in 4 neurons in the absence (left panels) and presence (right panels) of perampanel at the concentrations indicated. The percent inhibition values (derived from the current amplitude in the absence of perampanel and the corresponding current amplitude in the presence of perampanel) are 20%, 41%, 55%, and 80% at concentrations of 0.1, 0.3, 1, and 3 µM, respectively. (B) Current amplitude values evoked by various kainate concentrations expressed as percent of control prior to perampanel. Curves represent logistic fits to the data for each kainate concentration. Data points represent mean ± S.E.M. of values from 3 to 6 neurons.