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How Do Haloarchaea Synthesize Aromatic Amino Acids?

Figure 9

Protein sequence alignment of OE1472F from H. salinarum and MJ0400 from M. jannaschii.

Conserved sequence motifs of archaea, described by Siebers et al. [10], are marked with black boxes. Active site residues described by Morar et al. for M. jannaschii [9] are marked in boldface letters and red asterisks. The catalytic lysine residue (Lys237) determined for the E. coli class IA aldolase (DhnA type aldolase), is marked with a black asterisk [44]. Identical residues are colored yellow (43%), and similar residues are colored orange (61%). The alignment was done using ClustalW multiple sequence alignment program ( The secondary structure elements according to MJ0400 [9] are shown at the top of the alignment. Lower panel: Superposition of MJ0400-F1,6-P complex (PDB:2QJG) with OE1472F. Colours indicate: Blue, MJ0400; red, OE1472F; green, F-1,6-P. The PDB file of OE1472F was generated by Phyre ( and 3D structure was superimposed and viewed by Pymol (

Figure 9