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Comparative Analysis of Functional Metagenomic Annotation and the Mappability of Short Reads

Figure 2

The impact of phylogenetic coverage of the database on the performance of a translated BLAST-based annotation.

(a) The inner ring represents the proportion of the S. pneumonia genome annotated with KO genes, non-KO genes, and intergenic regions, as in Figure 1. Outer Rings illustrate the annotations for reads from each such category obtained with varying levels of phylogenetic coverage, ranging from having the strain from which the reads originated present in the database, to having only other genomes from the same species, genus, or higher taxonomic levels present. (b) The impact of phylogenetic database coverage on the annotation of B. fragilis, E. coli, S. elongatus, and M. maripaludis genomes.

Figure 2

doi: https://doi.org/10.1371/journal.pone.0105776.g002