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Amygdalin Blocks Bladder Cancer Cell Growth In Vitro by Diminishing Cyclin A and cdk2

Figure 3

Left: Cell proliferation in UMUC-3, TCCSUP and RT112 cells cultured without (control) and with 10 mg/ml amygdalin for 24 h or 2 weeks (OD = optical density).

Right: Clonogenic growth of TCCSUP and RT112 cells (subsequent to 2 week subconfluent culture with 10 mg/ml amygdalin) without (control) and with amygdalin. Amygdalin A = 10 day amygdalin free incubation during clonogenic growth. Amygdalin B = 10 day clonogenic growth with 10 mg/ml amygdalin. Experiments were done in triplicate and repeated 5 times. *indicates significant difference to controls (p = 0.0022). #indicates significant difference to amygdalin A (p = 0.0022).

Figure 3

doi: https://doi.org/10.1371/journal.pone.0105590.g003