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Elimination of Young Erythrocytes from Blood Circulation and Altered Erythropoietic Patterns during Paraquat Induced Anemic Phase in Mice

Figure 1

Induction of anemia and reticulocyte surge in paraquat treated mice.

Mice were administered repeated doses (10 mg/kg body weight, i.p on alternate days) of paraquat and blood samples were collected at different time points. Blood erythrocyte count (panel A) and hemoglobin levels (panel B) were measured using an electronic hematology particle counter at different time intervals. Reticulocyte estimation (panel C) was done by thiazole orange (TO) staining and flow cytometric analysis. Data is represented as mean ± SEM; n = 6 in control and 6–8 in treated groups. *p<0.05, **p<0.005 and ***p<0.0005.

Figure 1

doi: https://doi.org/10.1371/journal.pone.0099364.g001