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Heart Rate and Heart Rate Variability Assessment Identifies Individual Differences in Fear Response Magnitudes to Earthquake, Free Fall, and Air Puff in Mice

Figure 7

Effects of habituation on HR dynamics upon multiple trials of earthquake.

(A) The average rising speed showed no significant difference during seven trials of earthquake stimuli. n = 7. (B) The plateau durations of seven earthquake stimuli decreased significantly from the second trial and afterwards. n = 7; *P<0.05, **P<0.01, ***P<0.001, one-way repeated measures ANOVA and Dunnett’s multiple comparisons test. (C–D) In comparison to the pre-stimulus state, the significant changes of HR and CV during the maximum plateau maintained throughout seven trials. n = 7; ***P<0.001, one-way repeated measures ANOVA, Tukey post hoc test and Dunnett’s multiple comparisons test. (E) The recovery speed across seven earthquake stimuli exhibited a significant increasing trend over trials. n = 7; *P<0.05, **P<0.01, one-way repeated measures ANOVA and Dunnett’s multiple comparisons test. All data are plotted as mean ± SEM (error bars).

Figure 7

doi: https://doi.org/10.1371/journal.pone.0093270.g007