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Heart Rate and Heart Rate Variability Assessment Identifies Individual Differences in Fear Response Magnitudes to Earthquake, Free Fall, and Air Puff in Mice

Figure 4

Response of HR dynamics to free fall.

(A) Instant HR responses of an individual mouse during three free fall stimuli, trial #1, trial #4 and trial #7. The red vertical dashed lines indicate the onset of the free fall stimuli (13 cm high). (B) Poincaré plots of the same mouse’s R-R intervals of 30-s pre-stimulus (grey line) and 30-s post-stimulus (red line) period in trial #1, trial #4 and trial #7. Immediate decrease in dynamic patterns in HRV after stimulus onset was noted at trial #1, but more diffused distribution in the 30-s post-stimulus period in trial #4 and trial #7. (C) The average HR response to free fall (1st trial). (D) The average CV of R-R intervals upon 1st trial of free fall. (E) The average RMSSD of R-R intervals upon 1st trial of free fall. The average curves of 30-s pre-stimulus period were plotted as grey lines, whereas the average curves of 90-s post-stimulus period were plotted as red lines. The shadows around the average curves indicate error bars (SEM); n = 7.

Figure 4