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The CO-Regulation Database (CORD): A Tool to Identify Coordinately Expressed Genes

Figure 4

CORD results for VIM.

A) The epithelial-to-mesenchymal (EMT) and mesenchymal-to-epithelial transitions are important oncogenic pathways where vimentin (VIM) plays a central role. Twelve of the top 20 most correlated VIM genes affect the EMT transition. B) The EMT transitions depend heavily on cell adhesion. The VIM-correlated genes were over representative for several KEGG pathways in cell adhesion and cancer pathways such as “ECM-receptor interaction”, “Focal adhesion”, and “Pathways in cancer.”

Figure 4

doi: https://doi.org/10.1371/journal.pone.0090408.g004