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Episodic Positive Selection in the Evolution of Avian Toll-Like Receptor Innate Immunity Genes

Figure 1

Characteristics of substitutions occurring in ten Toll-like receptor loci in birds.

Frequency with which each amino-acid substitution type (N = 190 possible substitutions) was observed, relative to their predicted physicochemical distances [42] (A). The number of amino acid substitution types (N = 190) that were observed at least once in each of 10 avian TLR loci, as a function of the number of alignments in which each type was observed (B).

Figure 1

doi: https://doi.org/10.1371/journal.pone.0089632.g001