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Maternal Bisphenol A Exposure Impacts the Fetal Heart Transcriptome

Figure 3

Expression changes in Adam12-l mRNA.

Real-time PCR quantification of the long isoform of A Disintegrin And Metalloprotease (Adam12-l) expression in the left ventricle (LV), right ventricle (RV), left atrium (LA) and the right atrium (RA) of rhesus monkey (Macaca mulatta) fetuses at birth. Fetuses were exposed maternally to a 400 µg/Kg. body weight of BPA dose (B) or 150 µL ethanol (C) during late gestation (LG, days 100±2–term). Data were analyzed by tissue and bars represent the mean ± S.E.M. of the log2 (fold change). A two sample t-test was performed to identify significant BPA effects and a two-tailed p≤0.05 was considered statistically significant. Asterisk (*) indicate significantly different groups.

Figure 3

doi: https://doi.org/10.1371/journal.pone.0089096.g003