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Asymmetric Segregation of Damaged Cellular Components in Spatially Structured Multicellular Organisms

Figure 3

Effect of spatial structure and damage segregation.

For well mixed systems, where apoptotic cells can be replaced by any other dividing cell in the population, the time before system collapse increases drastically with the number of cells in the population. In systems with spatial structure, where apoptotic cells can only be replaced by neighboring cells, saturates with increasing , corresponding to an €effective system size for each cell. Both for spatial and well mixed systems, asymmetric division significantly increases the longevity of the cell population compared to symmetrically dividing populations of the same size. Notice that the asymmetric well mixed system has been studied using smaller cell populations due to the more rapid divergence of relative to the symmetric well mixed system. Each data point represents the median time before collapse out of 20 simulations. Parameters used: , , . Other choices of parameters yield similar results.

Figure 3