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Chemical and Genetic Validation of the Statin Drug Target to Treat the Helminth Disease, Schistosomiasis

Figure 6

Simvastatin, but not pravastatin, induces apoptosis in somules and adult worms.

A. Newly transformed somules were incubated in the presence of either 10 µM simvastatin (±100 µM mevalonate) or pravastatin for the times indicated. Caspase activity was then measured using the fluorescent substrate Z-DEVD-R110 as described in the text and is expressed relative to DMSO controls. Bars represent means ± S.D. across two independent experiments. Significance (p<0.05) was measured using Student's t-test and is indicated with an asterisk. B. As for A, but employing adult worms. Bars represent means ± S.D. across two independent experiments. Significance (p<0.05) was measured using Student's t-test and is indicated with an asterisk.

Figure 6

doi: https://doi.org/10.1371/journal.pone.0087594.g006