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Chemical and Genetic Validation of the Statin Drug Target to Treat the Helminth Disease, Schistosomiasis

Figure 5

RNAi of SmHMGR severely compromises parasite survival in vivo.

Newly transformed somules were incubated for 2.5 days in the presence of mCherry dsRNA or HMGR dsRNA as described in the text. Parasites were then injected subcutaneously into Swiss Webster mice (5 mice per dsRNA treatment). After 34 days, mice were euthanized and the portal system perfused to recover parasites for counting. Bars represent means ± S.D. across two independent experiments. Using Student's t-test, worm recovery after exposure to HMGR-dsRNA was significantly different from mCherry controls (p<0.01).

Figure 5