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Chemical and Genetic Validation of the Statin Drug Target to Treat the Helminth Disease, Schistosomiasis

Figure 4

RNAi of SmHMGR kills somules and killing is preventable by excess mevalonate.

Newly transformed somules were incubated for the times indicated in the presence of mCherry-dsRNA (control) or HMGR-dsRNA with and without the presence of 500 µM mevalonate, as described in the text. Bars represent means ± S.D. across two independent experiments each in duplicate. The number of degenerate worms in the HMGR-dsRNA-treated samples taken on Day 25 is significantly different from both the mCherry controls and HMG-dsRNA-treated samples that had also been incubated in the presence of mevalonate (Student's t-test; p<0.01). Image panels display somules on Day 25 incubated with (A) mCherry-dsRNA (control), (B) HMG-dsRNA and (C) HMG-dsRNA plus 500 µM mevalonate. Arrowheads highlight a dead (left) and degenerate worm (right). Bar in panel A = 100 µm.

Figure 4