Gene and MicroRNA Transcriptome Analysis of Parkinson's Related LRRK2 Mouse Models
Figure 2
miRNA microarray analysis of LRRK2 mice.
(A) Cluster analysis of significantly (FDR<0.2) misregulated mature miRNAs in various LRRK2 mouse models. Results were generated using Partek Genomics Suite. (B) Venn diagram showing variable overlap between significantly (FDR<0.2) misregulated miRNAs in LRRK2 mice. (C, D and E) Validation of miRNAs by real-time qRT-PCR, as indicated. Statistical significance was determined by a Student unpaired t test (* = p<0.05, ** = p<0.01, *** = p<0.001). Standard error of the mean (SEM) is shown.